Premenstrual dysphoric disorder (PMDD) PMDD is premenstrual syndrome (PMS) that is so severe it can be debilitating due to either physical, mental or emotional symptoms. PMDD afflicts an estimated 3% to 8% of women. PMDD is distinguished from PMS by the severity of symptoms, predominance of mood symptoms, and role dysfunction, particularly in personal relationships and marital/family domains. Treatment is recommended because PMDD interferes with the sufferer's ability to function in her social or occupational life.

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