Major depressive disorder (also known as clinical depression or major depression) is a mental disorder characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities. The general term depression is often used to denote the disorder; but as it can also be used in reference to other types of psychological depression, it is avoided in favor of more precise terminology for the disorder in clinical and research use. Major depression is a disabling condition which adversely affects a person's family, work or school life, sleeping and eating habits, and general health. In the United States, around 3.4% of people with major depression commit suicide, and up to 60% of people who commit suicide had depression or another mood disorder.
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